Hydrochloric Acid → HCID 67683445, compound

HRID 1550Notes

Reaction equation

HRID 1550 reaction equation
[OH:1][CH:2]([CH2:30][O:31][C:32]1[CH:37]=[CH:36][C:35]([OH:38])=[C:34]([CH2:39][OH:40])[CH:33]=1)[CH2:3][NH:4][CH:5]([CH3:29])[CH2:6][C:7]1[CH:28]=[CH:27][C:10]([CH2:11][P:12]([CH2:19][O:20][C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)(=[O:18])[O:13]CCCC)=[CH:9][CH:8]=1.Cl>>[OH:1][CH:2]([CH2:30][O:31][C:32]1[CH:37]=[CH:36][C:35]([OH:38])=[C:34]([CH2:39][OH:40])[CH:33]=1)[CH2:3][NH:4][CH:5]([CH3:29])[CH2:6][C:7]1[CH:28]=[CH:27][C:10]([CH2:11][P:12]([CH2:19][O:20][C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)(=[O:13])[OH:18])=[CH:9][CH:8]=1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 86752206(SR)-4-{2-[2-hydroxy-3-(4-hydroxy-3-hydroxymethyl-phenoxy)propylamino]propyl}phenoxymethylbenzylphosphinic acid, n-butyl ester

Product 1

HCID 67683445HCID 67683445, compound

Procedure

The title compound was prepared from (SR)-4-{2-[2-hydroxy-3-(4-hydroxy-3-hydroxymethyl-phenoxy)propylamino]propyl}phenoxymethylbenzylphosphinic acid, n-butyl ester according to the method described in Example 5 followed by acidification to pH 3.5 with 1M hydrochloric acid, as a solid (mp 180°-183° C.) following chromatography on C18 reverse phase silica-gel, eluting with 40% methanol in water.

Workup

  1. washeluting with 40% methanol in water

Sources & evidence

ORD record
ord-7dcfc77b6fae44dabea5f16d26269c62
Source dataset
uspto-grants-1998_03
Patent number
US05726165

Reaction notes

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