Acetone → 1-[4-(p-Fluorophenyl)-4-hydroxy-2-butenyl]-4-(p-chlorophenyl)-4-hydroxypiperidine
Reaction equation
[Al+3:2].[CH3:33][C:34](=[O:35])[CH3:36].[F:7][c:8]1[cH:9][cH:10][c:11]([CH:14]([C:15]#[C:16][CH2:17][N:18]2[CH2:19][CH2:20][C:21]([OH:24])([c:25]3[cH:26][cH:27][c:28]([Cl:31])[cH:29][cH:30]3)[CH2:22][CH2:23]2)[OH:32])[cH:12][cH:13]1.[H-:1].[H-:4].[H-:5].[H-:6].[Li+:3]>>[F:7][c:8]1[cH:9][cH:10][c:11]([CH:14]([CH:15]=[CH:16][CH2:17][N:18]2[CH2:19][CH2:20][C:21]([OH:24])([c:25]3[cH:26][cH:27][c:28]([Cl:31])[cH:29][cH:30]3)[CH2:22][CH2:23]2)[OH:32])[cH:12][cH:13]1Participants
6
Sources & evidence
- ORD record
- ord-80fb3568ff57442cb2c9f074c374b2ac
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (1/10)
Reaction notes
Loading…