Acetate → Tert-butyl 3-[4-[cyclohexylidene-(3-fluoro-4-hydroxyphenyl)methyl]phenyl]prop-2-enoate

HRID 1550663Notes

Reaction equation

HRID 1550663 reaction equation
[Br:1][c:2]1[cH:3][cH:4][c:5]([C:8]([c:9]2[cH:10][c:11]([F:16])[c:12]([OH:15])[cH:13][cH:14]2)=[C:17]2[CH2:18][CH2:19][CH2:20][CH2:21][CH2:22]2)[cH:6][cH:7]1.[C:23]([CH:24]=[CH2:25])(=[O:26])[O:27][C:28]([CH3:29])([CH3:30])[CH3:31].[C:39]([O-:40])(=[O:41])[CH3:42].[C:44]([O-:45])(=[O:46])[CH3:47].[CH3:32][CH2:33][N:34]([CH2:35][CH3:36])[CH2:37][CH3:38].[OH2:48].[Pd+2:43]>>[c:2]1([CH:25]=[CH:24][C:23](=[O:26])[O:27][C:28]([CH3:29])([CH3:30])[CH3:31])[cH:3][cH:4][c:5]([C:8]([c:9]2[cH:10][c:11]([F:16])[c:12]([OH:15])[cH:13][cH:14]2)=[C:17]2[CH2:18][CH2:19][CH2:20][CH2:21][CH2:22]2)[cH:6][cH:7]1

Participants

7

Reactant 6

HCID 175Acetate2×HCID 962WaterHCID 8471TriethylamineHCID 15458tert-Butyl acrylateHCID 105144Allyl(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)chloropalladium(II)HCID 686545304-[(4-Bromophenyl)(cyclohexylidene)methyl]-2-fluorophenol

Product 1

HCID 68976302Tert-butyl 3-[4-[cyclohexylidene-(3-fluoro-4-hydroxyphenyl)methyl]phenyl]prop-2-enoate

Sources & evidence

ORD record
ord-ae3302ded81147598ab6cacb149b4634
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (1/10)

Reaction notes

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