Trifluoroacetic acid → [8-(2-Methoxy-5-trifluoromethyl-phenyl)-[1,2,4]triazolo[1,5-a]pyridine-2-yl]-(1,2,3,4-tetrahydro-isoquinolin-6-yl)-amine

HRID 1550885Notes

Reaction equation

HRID 1550885 reaction equation
[C:1]([O:2][C:3](=[O:4])[N:8]1[CH2:9][c:10]2[cH:11][cH:12][c:13]([NH:18][c:19]3[n:20][n:21]4[c:22]([c:23](-[c:27]5[c:28]([O:37][CH3:38])[cH:29][cH:30][c:31]([C:33]([F:34])([F:35])[F:36])[cH:32]5)[cH:24][cH:25][cH:26]4)[n:39]3)[cH:14][c:15]2[CH2:16][CH2:17]1)([CH3:5])([CH3:6])[CH3:7].[OH:40][C:41]([C:42]([F:43])([F:44])[F:45])=[O:46]>>[NH:8]1[CH2:9][c:10]2[cH:11][cH:12][c:13]([NH:18][c:19]3[n:20][n:21]4[c:22]([c:23](-[c:27]5[c:28]([O:37][CH3:38])[cH:29][cH:30][c:31]([C:33]([F:34])([F:35])[F:36])[cH:32]5)[cH:24][cH:25][cH:26]4)[n:39]3)[cH:14][c:15]2[CH2:16][CH2:17]1

Participants

3

Reactant 2

HCID 6422Trifluoroacetic acidHCID 596126096-[8-(2-Methoxy-5-trifluoromethyl-phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino]-3,4-dihydro-1H-isoquinoline-2-carboxylic acid tert-butyl ester

Product 1

HCID 49838140[8-(2-Methoxy-5-trifluoromethyl-phenyl)-[1,2,4]triazolo[1,5-a]pyridine-2-yl]-(1,2,3,4-tetrahydro-isoquinolin-6-yl)-amine

Sources & evidence

ORD record
ord-67813d945bd14248bcccf35ee9f1e4e4
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (1/10)

Reaction notes

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