Water → (+/-)-4-(3-chlorophenyl)-6-[hydroxy[4-(1-hydroxyethyl)phenyl](1-methyl-1H-imidazol-5-yl)methyl]-1-methyl-2(1H)-quinolinone

HRID 1551367Notes

Reaction equation

HRID 1551367 reaction equation
[CH2:39]1[O:40][CH2:41][CH2:42][CH2:43]1.[CH3:1][Li:2].[Cl:3][c:4]1[cH:5][c:6](-[c:10]2[cH:11][c:12](=[O:37])[n:13]([CH3:36])[c:14]3[cH:15][cH:16][c:17]([C:20]([c:21]4[cH:22][cH:23][c:24]([CH:25]=[O:26])[cH:27][cH:28]4)([c:29]4[cH:30][n:31][cH:32][n:33]4[CH3:34])[OH:35])[cH:18][c:19]23)[cH:7][cH:8][cH:9]1.[OH2:38]>>[CH3:1][CH:25]([c:24]1[cH:23][cH:22][c:21]([C:20]([c:17]2[cH:16][cH:15][c:14]3[n:13]([CH3:36])[c:12](=[O:37])[cH:11][c:10](-[c:6]4[cH:5][c:4]([Cl:3])[cH:9][cH:8][cH:7]4)[c:19]3[cH:18]2)([c:29]2[cH:30][n:31][cH:32][n:33]2[CH3:34])[OH:35])[cH:28][cH:27]1)[OH:26]

Participants

5

Reactant 4

HCID 962WaterHCID 8028TetrahydrofuranHCID 10299684(+/-)-4-[[4-(3-chlorophenyl)-1,2-dihydro-1-methyl-2-oxo-6-quinolinyl]hydroxy(1-methyl-1H-imidazol-5-yl)methyl]benzaldehydeHCID 178418348HCID 178418348, compound

Product 1

HCID 21082093(+/-)-4-(3-chlorophenyl)-6-[hydroxy[4-(1-hydroxyethyl)phenyl](1-methyl-1H-imidazol-5-yl)methyl]-1-methyl-2(1H)-quinolinone

Sources & evidence

ORD record
ord-83a7ddb0af2f4ebeb822429d12352f08
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (1/10)

Reaction notes

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