Dichloromethane → 2-N-(2-amino-5-fluorophenyl)-4-N-(8-fluoro-3,4-dihydro-2H-chromen-4-yl)-5-nitropyrimidine-2,4-diamine

HRID 1551534Notes

Reaction equation

HRID 1551534 reaction equation
[Cl:45][CH2:46][Cl:47].[F:1][c:2]1[cH:3][c:4]([NH:16][c:17]2[n:18][cH:19][c:20]([N+:35](=[O:36])[O-:37])[c:21]([NH:23][CH:24]3[CH2:25][CH2:26][O:27][c:28]4[c:29]([F:34])[cH:30][cH:31][cH:32][c:33]43)[n:22]2)[c:5]([NH:8][C:9](=[O:10])[O:11][C:12]([CH3:13])([CH3:14])[CH3:15])[cH:6][cH:7]1.[F:38][C:39]([F:40])([F:41])[C:42]([OH:43])=[O:44]>>[F:1][c:2]1[cH:3][c:4]([NH:16][c:17]2[n:18][cH:19][c:20]([N+:35](=[O:36])[O-:37])[c:21]([NH:23][CH:24]3[CH2:25][CH2:26][O:27][c:28]4[c:29]([F:34])[cH:30][cH:31][cH:32][c:33]43)[n:22]2)[c:5]([NH2:8])[cH:6][cH:7]1

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 66970498tert-butyl N-[4-fluoro-2-[[4-[(8-fluoro-3,4-dihydro-2H-chromen-4-yl)amino]-5-nitropyrimidin-2-yl]amino]phenyl]carbamate

Product 1

HCID 669706182-N-(2-amino-5-fluorophenyl)-4-N-(8-fluoro-3,4-dihydro-2H-chromen-4-yl)-5-nitropyrimidine-2,4-diamine

Sources & evidence

ORD record
ord-bcd46aae5ff04ed2933c3a164f8295b2
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (1/10)

Reaction notes

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