Acetate → ethyl 7-pyrrolidin-1-yl-2-(trifluoromethyl)-2H-chromene-3-carboxylate

HRID 1552264Notes

Reaction equation

HRID 1552264 reaction equation
[C:21](=[O:22])([O-:23])[O-:24].[CH2:27]1[CH2:28][CH2:29][NH:30][CH2:31]1.[CH3:32][c:33]1[cH:34][cH:35][cH:36][cH:37][cH:38]1.[CH3:39][CH2:40][CH2:41][CH2:42][CH2:43][CH3:44].[Cs+:25].[Cs+:26].[I:1][c:2]1[cH:3][cH:4][c:5]2[c:10]([cH:11]1)[O:9][CH:8]([C:12]([F:13])([F:14])[F:15])[C:7]([C:16](=[O:17])[O:18][CH2:19][CH3:20])=[CH:6]2.[O-:46][C:47]([CH3:48])=[O:49].[O-:50][C:51]([CH3:52])=[O:53].[Pd+2:45]>>[c:2]1([N:30]2[CH2:29][CH2:28][CH2:27][CH2:31]2)[cH:3][cH:4][c:5]2[c:10]([cH:11]1)[O:9][CH:8]([C:12]([F:13])([F:14])[F:15])[C:7]([C:16](=[O:17])[O:18][CH2:19][CH3:20])=[CH:6]2

Participants

9

Reactant 8

HCID 175Acetate2×HCID 1140TolueneHCID 8058HexaneHCID 19660Carbonate IonHCID 31268PyrrolidineHCID 104967Cesium cation2×HCID 105144Allyl(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)chloropalladium(II)HCID 69517680ethyl 7-iodo-2-(trifluoromethyl)-2H-chromene-3-carboxylate

Product 1

HCID 69518242ethyl 7-pyrrolidin-1-yl-2-(trifluoromethyl)-2H-chromene-3-carboxylate

Sources & evidence

ORD record
ord-1aef11fad01f46629a263c92b72c778e
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (1/10)

Reaction notes

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