Dichloromethane → 7-(Piperidin-4-yloxy)-3,4-dihydroquinolin-2(1H)-one

HRID 1552682Notes

Reaction equation

HRID 1552682 reaction equation
[Cl:33][CH2:34][Cl:35].[O:1]=[C:2]1[NH:3][c:4]2[cH:5][c:6]([O:12][CH:13]3[CH2:14][CH2:15][N:16]([C:19]([O:20][C:21]([CH3:22])([CH3:23])[CH3:24])=[O:25])[CH2:17][CH2:18]3)[cH:7][cH:8][c:9]2[CH2:10][CH2:11]1.[OH:26][C:27]([C:28]([F:29])([F:30])[F:31])=[O:32]>>[O:1]=[C:2]1[NH:3][c:4]2[cH:5][c:6]([O:12][CH:13]3[CH2:14][CH2:15][NH:16][CH2:17][CH2:18]3)[cH:7][cH:8][c:9]2[CH2:10][CH2:11]1

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 57575910tert-Butyl 4-(2-oxo-1,2,3,4-tetrahydroquinolin-7-yloxy)piperidine-1-carboxylate

Product 1

HCID 179651447-(Piperidin-4-yloxy)-3,4-dihydroquinolin-2(1H)-one

Sources & evidence

ORD record
ord-3cc1ef279aaf43ad8c2b13f1e5aef67c
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (1/10)

Reaction notes

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