反应详情

The product of step d.) was treated with trifluoroacetic acid (TFA) (2 mL) for 2 hours, concentrated, and purified by preparative LCMS to give the title compound. 1H NMR (d6-DMSO) δ10.01 (br s, 1H), 7.74 (dd, J=5.3 Hz, J=8.7 Hz, 2H), 7.35 (t, J=8.7 Hz, 2H), 7.19 (d, J=1.8 Hz, 1H), 6.87 (dd, J=1.8 Hz, J=8.7 Hz, 1H), 4.93 (s, 2H), 2.67 (t, J=7.5 Hz, 2H), 1.72 (sextet, J=7.5 Hz, 2H), 0.95 (t, J=7.5 Hz, 3H). MS: ESI (negative): 390 (M−H).

1. concentrationconcentrated
2. custompurified by preparative LCMS