Toluene → 2-Chloro-4-((6-methylpyridin-3-yl)methoxy)pyridine

HRID 1552912Notes

Reaction equation

HRID 1552912 reaction equation
[C:18](=[O:19])([O-:20])[O-:21].[CH3:1][c:2]1[cH:3][cH:4][c:5]([CH2:8][OH:9])[cH:6][n:7]1.[CH3:38][c:39]1[cH:40][cH:41][cH:42][cH:43][cH:44]1.[Cl:10][c:11]1[n:12][cH:13][cH:14][c:15]([I:17])[cH:16]1.[Cs+:22].[Cs+:23].[Cu:45][I:46].[cH:24]1[cH:25][c:26]2[cH:27][cH:28][c:29]3[c:30]([c:31]2[n:32][cH:33]1)[n:34][cH:35][cH:36][cH:37]3>>[CH3:1][c:2]1[cH:3][cH:4][c:5]([CH2:8][O:9][c:15]2[cH:14][cH:13][n:12][c:11]([Cl:10])[cH:16]2)[cH:6][n:7]1

Participants

8

Reactant 7

HCID 1140TolueneHCID 13181,10-PhenanthrolineHCID 19660Carbonate IonHCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)HCID 104967Cesium cation2×HCID 15165112-Chloro-4-iodopyridineHCID 11228788(6-Methylpyridin-3-yl)methanol

Product 1

HCID 580923082-Chloro-4-((6-methylpyridin-3-yl)methoxy)pyridine

Sources & evidence

ORD record
ord-7dc61d10ac3d43fb99601c2608b3057b
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (1/10)

Reaction notes

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