(5-tert-Butoxycarbonylamino-2-propyl-benzoimidazol-1-yl)-acetic acid tert-butyl ester → (5-Amino-2-propyl-benzoimidazol-1-yl)-acetic acid tert-butyl ester

HRID 15534Notes

Reaction equation

HRID 15534 reaction equation
[C:1]([O:5][C:6](=[O:28])[CH2:7][N:8]1[C:12]2[CH:13]=[CH:14][C:15]([NH:17]C(OC(C)(C)C)=O)=[CH:16][C:11]=2[N:10]=[C:9]1[CH2:25][CH2:26][CH3:27])([CH3:4])([CH3:3])[CH3:2]>Cl.O1CCOCC1>[C:1]([O:5][C:6](=[O:28])[CH2:7][N:8]1[C:12]2[CH:13]=[CH:14][C:15]([NH2:17])=[CH:16][C:11]=2[N:10]=[C:9]1[CH2:25][CH2:26][CH3:27])([CH3:4])([CH3:3])[CH3:2]

Participants

4

Reactant 1

HCID 67199280(5-tert-Butoxycarbonylamino-2-propyl-benzoimidazol-1-yl)-acetic acid tert-butyl ester

Product 1

HCID 67200153(5-Amino-2-propyl-benzoimidazol-1-yl)-acetic acid tert-butyl ester

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidSolventHCID 312751,4-DioxaneSolvent

Procedure

The product of example 25, step d.) (140 mg, 0.359 mmol) was stirred in 4 M HCl in dioxane (1 mL) at ambient temperature for an hour. The reaction was concentrated to give the sub-title compound that was used in crude form without purification. MS: ESI (positive): 290 (M+H).

Workup

  1. concentrationThe reaction was concentrated

Sources & evidence

ORD record
ord-7127dda99fa6496f990591c54edd8f2f
Source dataset
uspto-grants-2010_06
Patent number
US07732618B2

Reaction notes

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