(4-Nitro-2-propyl-benzoimidazol-1-yl)-acetic acid tert-butyl ester → (4-Amino-2-propyl-benzoimidazol-1-yl)-acetic acid tert-butyl ester

HRID 15537Notes

Reaction equation

HRID 15537 reaction equation
[C:1]([O:5][C:6](=[O:23])[CH2:7][N:8]1[C:12]2[CH:13]=[CH:14][CH:15]=[C:16]([N+:17]([O-])=O)[C:11]=2[N:10]=[C:9]1[CH2:20][CH2:21][CH3:22])([CH3:4])([CH3:3])[CH3:2]>[Pd]>[C:1]([O:5][C:6](=[O:23])[CH2:7][N:8]1[C:12]2[CH:13]=[CH:14][CH:15]=[C:16]([NH2:17])[C:11]=2[N:10]=[C:9]1[CH2:20][CH2:21][CH3:22])([CH3:4])([CH3:3])[CH3:2]

Participants

3

Reactant 1

HCID 67200283(4-Nitro-2-propyl-benzoimidazol-1-yl)-acetic acid tert-butyl ester

Product 1

HCID 67201653(4-Amino-2-propyl-benzoimidazol-1-yl)-acetic acid tert-butyl ester

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

The sub-title compound was prepared by the method of example 1, step c.) using (4-nitro-2-propyl-benzoimidazol-1-yl)-acetic acid tert-butyl ester (regioisomer 2) from step b.) and 10% Pd/C and was used in crude form without purification. MS: ESI (positive): 290 (M+H).

Workup

  1. customwithout purification

Sources & evidence

ORD record
ord-157e01ed52c84621a5044a9ce246d734
Source dataset
uspto-grants-2010_06
Patent number
US07732618B2

Reaction notes

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