Benzyl Bromide → HCID 68494209, compound

Participants

Role	Name	HCID	Charge
Reactant	Benzyl Bromide	HCID 7498	—
Reactant	Potassium Carbonate	HCID 11430	—
Reactant	[4-(3-Fluoro-benzenesulfonylamino)-2-propyl-benzoimidazol-1-yl]-acetic acid tert-butyl ester	HCID 67200632	—
Solvent	Dimethylformamide	HCID 6228	—
Product	HCID 68494209	HCID 68494209	—

Reaction Conditions

Temperature	80 °C

Reaction Steps

The product from step d.) (45 mg, 0.103 mmol) was dissolved in DMF (1 mL), treated with K2CO3 (20 mg, 0.145 mmol), benzyl bromide (25 μL, 0.206 mmol), and stirred at 80° C. for 3.5 hours. The reaction mixture was partitioned between ethyl acetate and water. The organic layer was washed several times with water and concentrated under reduced pressure to give the sub-title compound that was used in crude form without purification.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07732618B2
Source dataset	uspto-grants-2010_06
ORD ID	ord-2ce49d6a9c5c4b06ad82b01de48c98b6
Source note	uspto-grants-2010_06