2-Aminopropanol → 3-difluoromethyl-1-methyl-1H-pyrazole-4-carboxylic acid (2-hydroxy-1-methyl-ethyl)-amide

HRID 1554366Notes

Reaction equation

[CH3:18][CH2:19][N:20]([CH2:21][CH3:22])[CH2:23][CH3:24].[Cl:25][CH2:26][Cl:27].[F:1][CH:2]([c:3]1[n:4][n:5]([CH3:11])[cH:6][c:7]1[C:8](=[O:9])[Cl:10])[F:12].[NH2:13][CH:14]([CH3:15])[CH2:16][OH:17]>>[F:1][CH:2]([c:3]1[n:4][n:5]([CH3:11])[cH:6][c:7]1[C:8](=[O:9])[NH:13][CH:14]([CH3:15])[CH2:16][OH:17])[F:12]

Participants

Reactant 4

HCID 51262-Aminopropanol

HCID 6344Dichloromethane

HCID 8471Triethylamine

HCID 153401103-(Difluoromethyl)-1-methyl-1 H-pyrazole-4-carbonyl chloride

Product 1

HCID 582314523-difluoromethyl-1-methyl-1H-pyrazole-4-carboxylic acid (2-hydroxy-1-methyl-ethyl)-amide

Sources & evidence

ORD record: ord-1d3e26526f194f98990f27ea82926674
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (1/10)
DOI: 10.1039/C8SC04228D

Reaction notes

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