Acetate → N-(4'-amino-biphenyl-2-ylmethyl)-2,2,2-trifluoro-acetamide

HRID 1555223Notes

Reaction equation

HRID 1555223 reaction equation
[Br:1][c:2]1[c:3]([CH2:4][NH:5][C:6]([C:7]([F:8])([F:9])[F:10])=[O:11])[cH:12][cH:13][cH:14][cH:15]1.[CH3:16][C:17]1([CH3:18])[C:19]([CH3:20])([CH3:21])[O:22][B:23]([c:24]2[cH:25][cH:26][c:27]([NH2:28])[cH:29][cH:30]2)[O:31]1.[K+:32].[K+:33].[O-:34][C:35]([O-:36])=[O:37].[O-:44][C:45]([CH3:46])=[O:47].[O-:48][C:49]([CH3:50])=[O:51].[O:38]=[CH:39][N:40]([CH3:41])[CH3:42].[Pd+2:43]>>[c:2]1(-[c:24]2[cH:25][cH:26][c:27]([NH2:28])[cH:29][cH:30]2)[c:3]([CH2:4][NH:5][C:6]([C:7]([F:8])([F:9])[F:10])=[O:11])[cH:12][cH:13][cH:14][cH:15]1

Participants

8

Reactant 7

HCID 175Acetate2×HCID 813Potassium Cation2×HCID 6228DimethylformamideHCID 19660Carbonate IonHCID 105144Allyl(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)chloropalladium(II)HCID 27346204-(Tetramethyl-1,3,2-dioxaborolan-2-yl)anilineHCID 57470274Acetamide, N-[(2-bromophenyl)methyl]-2,2,2-trifluoro-

Product 1

HCID 57482727N-(4'-amino-biphenyl-2-ylmethyl)-2,2,2-trifluoro-acetamide

Sources & evidence

ORD record
ord-ec86f554aed44a09ba5b44aa295e9807
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (1/10)

Reaction notes

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