Methanol → (9-(3-(2-Hydroxyethyl)benzyl)-2,2-dimethyl-1-oxa-4,9-diazaspiro[5.5]undecan-4-yl)(2-methylthiazol-4-yl)methanone

HRID 1555982Notes

Reaction equation

HRID 1555982 reaction equation
[CH3:1][C:2]1([CH3:23])[O:3][C:4]2([CH2:5][NH:6][CH2:7]1)[CH2:8][CH2:9][N:10]([CH2:13][c:14]1[cH:15][c:16]([CH2:20][CH2:21][OH:22])[cH:17][cH:18][cH:19]1)[CH2:11][CH2:12]2.[CH3:24][c:25]1[s:26][cH:27][c:28]([C:30](=[O:31])[OH:32])[n:29]1.[CH3:33][OH:34].[CH3:35][CH2:36][N:37]([CH2:38][CH3:39])[CH2:40][CH3:41].[Cl:42][CH2:43][Cl:44]>>[CH3:1][C:2]1([CH3:23])[O:3][C:4]2([CH2:5][N:6]([C:30]([c:28]3[cH:27][s:26][c:25]([CH3:24])[n:29]3)=[O:31])[CH2:7]1)[CH2:8][CH2:9][N:10]([CH2:13][c:14]1[cH:15][c:16]([CH2:20][CH2:21][OH:22])[cH:17][cH:18][cH:19]1)[CH2:11][CH2:12]2

Participants

6

Reactant 5

HCID 887MethanolHCID 6344DichloromethaneHCID 8471TriethylamineHCID 2847282-Methyl-1,3-thiazole-4-carboxylic acidHCID 579890912-(3-((2,2-Dimethyl-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl)methyl)phenyl)ethanol

Product 1

HCID 57989096(9-(3-(2-Hydroxyethyl)benzyl)-2,2-dimethyl-1-oxa-4,9-diazaspiro[5.5]undecan-4-yl)(2-methylthiazol-4-yl)methanone

Sources & evidence

ORD record
ord-3db44db8fb6d4e5aae9e32bb59ff148d
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (1/10)

Reaction notes

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