Potassium Carbonate → {5-[But-2-enyl-(4-fluoro-benzenesulfonyl)-amino]-2-propyl-benzoimidazol-1-yl}-acetic acid tert-butyl ester

HRID 15572ノート

反応式

HRID 15572 の反応式
[CH2:1](Br)[CH:2]=[CH:3][CH3:4].C([O-])([O-])=O.[K+].[K+].[C:12]([O:16][C:17](=[O:42])[CH2:18][N:19]1[C:23]2[CH:24]=[CH:25][C:26]([NH:28][S:29]([C:32]3[CH:37]=[CH:36][C:35]([F:38])=[CH:34][CH:33]=3)(=[O:31])=[O:30])=[CH:27][C:22]=2[N:21]=[C:20]1[CH2:39][CH2:40][CH3:41])([CH3:15])([CH3:14])[CH3:13]>CC#N.CCOC(C)=O.O>[C:12]([O:16][C:17](=[O:42])[CH2:18][N:19]1[C:23]2[CH:24]=[CH:25][C:26]([N:28]([CH2:1][CH:2]=[CH:3][CH3:4])[S:29]([C:32]3[CH:33]=[CH:34][C:35]([F:38])=[CH:36][CH:37]=3)(=[O:30])=[O:31])=[CH:27][C:22]=2[N:21]=[C:20]1[CH2:39][CH2:40][CH3:41])([CH3:15])([CH3:14])[CH3:13]

参加物

7

反応物 3

HCID 11430Potassium CarbonateHCID 1224142-Butene, 1-bromo-HCID 67201670[5-(4-Fluoro-benzenesulfonylamino)-2-propyl-benzoimidazol-1-yl]-acetic acid tert-butyl ester

生成物 1

HCID 67200276{5-[But-2-enyl-(4-fluoro-benzenesulfonyl)-amino]-2-propyl-benzoimidazol-1-yl}-acetic acid tert-butyl ester

試薬・触媒・溶媒 3

HCID 962Water溶媒HCID 6342Acetonitrile溶媒HCID 8857Ethyl Acetate溶媒

反応条件

温度
80 °C

実験手順

Crotyl bromide (0.27 mmol) and K2CO3 (63 mg, 0.45 mmol) were added to a solution of [5-(4-fluoro-benzenesulfonylamino)-2-propyl-benzoimidazol-1-yl]-acetic acid tert-butyl ester (40 mg, 0.09 mmol) in CH3CN (1 mL), and stirred overnight at 80° C. The reaction mixture was diluted with EtOAc and H2O, and then filtered through an Extrelut column. The column was washed with EtOAc, and the filtrate was concentrated. The crude product was carried onto the next reaction without any further purification or characterization.

後処理

  1. filtrationfiltered through an Extrelut column
  2. washThe column was washed with EtOAc
  3. concentrationthe filtrate was concentrated
  4. customThe crude product was carried onto the next reaction without any further purification or characterization

出典と根拠

ORDレコード
ord-fc6b4ce2da804b538584cdc7147b8e4d
出典データセット
uspto-grants-2010_06
特許番号
US07732618B2

反応ノート

読み込み中…