HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → {5-[But-2-enyl-(4-fluoro-benzenesulfonyl)-amino]-2-propyl-benzoimidazol-1-yl}-acetic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | {5-[But-2-enyl-(4-fluoro-benzenesulfonyl)-amino]-2-propyl-benzoimidazol-1-yl}-acetic acid tert-butyl ester | HCID 67200276 | — |
| Product | {5-[But-2-enyl-(4-fluoro-benzenesulfonyl)-amino]-2-propyl-benzoimidazol-1-yl}-acetic acid | HCID 67200878 | — |
Reaction Steps
{5-[But-2-enyl-(4-fluoro-benzenesulfonyl)-amino]-2-propyl-benzoimidazol-1-yl}-acetic acid tert-butyl ester was treated with TFA (2 mL) for 2 hours, concentrated, and purified by preparative LCMS to give the title compound. MS calculated for C22H24FN3O4S—H: 444, observed: 444.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07732618B2 |
| Source dataset | uspto-grants-2010_06 |
| ORD ID | ord-e6c18f4c7450407ba5d9ec6983c9506f |
| Source note | uspto-grants-2010_06 |