Triphenylphosphine → 1-{4'-[4-(1-Hydroxy-2-methyl-but-3-enyl)-3-methyl-isoxazol-5-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid ethyl ester

HRID 1557447Notes

Reaction equation

HRID 1557447 reaction equation
[Br:1][c:2]1[cH:3][cH:4][c:5](-[c:8]2[c:9]([CH:14]([CH:15]([CH:16]=[CH2:17])[CH3:18])[OH:19])[c:10]([CH3:13])[n:11][o:12]2)[cH:6][cH:7]1.[CH2:20]([CH3:21])[O:22][C:23](=[O:24])[C:25]1([c:28]2[cH:29][cH:30][c:31]([B:34]3[O:35][C:36]([CH3:37])([CH3:38])[C:39]([CH3:40])([CH3:41])[O:42]3)[cH:32][cH:33]2)[CH2:26][CH2:27]1.[Pd:43]([Cl:44])[Cl:45].[c:46]1([P:47]([c:48]2[cH:49][cH:50][cH:51][cH:52][cH:53]2)[c:54]2[cH:55][cH:56][cH:57][cH:58][cH:59]2)[cH:60][cH:61][cH:62][cH:63][cH:64]1.[c:65]1([P:66]([c:67]2[cH:68][cH:69][cH:70][cH:71][cH:72]2)[c:73]2[cH:74][cH:75][cH:76][cH:77][cH:78]2)[cH:79][cH:80][cH:81][cH:82][cH:83]1>>[c:2]1(-[c:31]2[cH:30][cH:29][c:28]([C:25]3([C:23]([O:22][CH2:20][CH3:21])=[O:24])[CH2:26][CH2:27]3)[cH:33][cH:32]2)[cH:3][cH:4][c:5](-[c:8]2[c:9]([CH:14]([CH:15]([CH:16]=[CH2:17])[CH3:18])[OH:19])[c:10]([CH3:13])[n:11][o:12]2)[cH:6][cH:7]1

Participants

5

Reactant 4

HCID 11776Triphenylphosphine2×HCID 24290Palladium ChlorideHCID 53217182Ethyl 1-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)cyclopropanecarboxylateHCID 665821181-[5-(4-Bromo-phenyl)-3-methyl-isoxazol-4-yl]-2-methyl-but-3-en-1-ol

Product 1

HCID 665773841-{4'-[4-(1-Hydroxy-2-methyl-but-3-enyl)-3-methyl-isoxazol-5-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid ethyl ester

Sources & evidence

ORD record
ord-1c75b33c2cb14c9ab14bda15d1c9d3b9
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (1/10)

Reaction notes

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