Acetic Acid → 4-Chloro-3,5-difluoro-2-(1-hydroxy-2-propyl)pyridine
Reaction equation
[CH2:31]1[O:32][CH2:33][CH2:34][CH2:35]1.[CH3:21][C:22](=[O:23])[OH:24].[Cl:1][c:2]1[c:3]([F:19])[c:4]([CH:9]([CH2:10][O:11][CH:12]2[CH2:13][CH2:14][CH2:15][CH2:16][O:17]2)[CH3:18])[n:5][cH:6][c:7]1[F:8].[Na+:25].[Na+:26].[O-:27][C:28](=[O:29])[O-:30].[OH2:20]>>[Cl:1][c:2]1[c:3]([F:19])[c:4]([CH:9]([CH2:10][OH:11])[CH3:18])[n:5][cH:6][c:7]1[F:8]Participants
7
Sources & evidence
- ORD record
- ord-65a688f9461a4c25ad8ca562644c22d8
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (1/10)
Reaction notes
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