Benzene → 1-N-Boc-4-Piperidinecarboxylic acid methyl ester

HRID 1558367Notes

Reaction equation

HRID 1558367 reaction equation
[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][CH:11]([C:12](=[O:13])[OH:14])[CH2:15][CH2:16]1.[CH3:17][OH:18].[CH3:19][Si:20]([CH:21]=[N+:22]=[N-:23])([CH3:24])[CH3:25].[cH:26]1[cH:27][cH:28][cH:29][cH:30][cH:31]1>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][CH:11]([C:12]([O:13][CH3:19])=[O:14])[CH2:15][CH2:16]1

Participants

5

Reactant 4

HCID 241BenzeneHCID 887MethanolHCID 167693TrimethylsilyldiazomethaneHCID 3928711-(tert-Butoxycarbonyl)-4-piperidinecarboxylic acid

Product 1

HCID 3928701-N-Boc-4-Piperidinecarboxylic acid methyl ester

Sources & evidence

ORD record
ord-a5cec3df718a4c08ad07f5feb383c229
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (1/10)

Reaction notes

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