Dichloromethane → 1-(4-(6-(2-Amino-5-bromonicotinoyl)pyridin-2-yl)-1,4-diazepan-1-yl)-3,3,3-trifluoropropan-1-one
Reaction equation
[CH3:42][CH2:43][N:44]([CH2:45][CH3:46])[CH2:47][CH3:48].[Cl:49][CH2:50][Cl:51].[F:24][C:25]([CH2:26][C:27](=[O:28])[OH:29])([F:30])[F:31].[N:1]1([c:8]2[cH:9][cH:10][cH:11][c:12]([C:14](=[O:15])[c:16]3[c:17]([NH2:23])[n:18][cH:19][c:20]([Br:22])[cH:21]3)[n:13]2)[CH2:2][CH2:3][NH:4][CH2:5][CH2:6][CH2:7]1.[OH:32][n:33]1[c:34]2[cH:35][cH:36][cH:37][cH:38][c:39]2[n:40][n:41]1>>[N:1]1([c:8]2[cH:9][cH:10][cH:11][c:12]([C:14](=[O:15])[c:16]3[c:17]([NH2:23])[n:18][cH:19][c:20]([Br:22])[cH:21]3)[n:13]2)[CH2:2][CH2:3][N:4]([C:27]([CH2:26][C:25]([F:24])([F:30])[F:31])=[O:28])[CH2:5][CH2:6][CH2:7]1Participants
6
Reactant 5
Product 1
Sources & evidence
- ORD record
- ord-fec34b8849ce4dc391a00ddce74063ea
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (1/10)
Reaction notes
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