Dichloromethane → racemic (2'R,3R,4'S)-6-chloro-4'-(3-chlorophenyl)-1'-methyl-2'-(2-methylphenyl)spiro[3H-indole-3,3'-piperidine]-2,6'(1H)-dione

HRID 1559375Notes

Reaction equation

HRID 1559375 reaction equation
[C:8]([O:9][C:10](=[O:11])[N:15]1[C:16](=[O:46])[C:17]2([c:18]3[cH:19][cH:20][c:21]([Cl:24])[cH:22][c:23]31)[CH:25]([c:39]1[c:40]([CH3:45])[cH:41][cH:42][cH:43][cH:44]1)[N:26]([CH3:38])[C:27](=[O:37])[CH2:28][CH:29]2[c:30]1[cH:31][c:32]([Cl:36])[cH:33][cH:34][cH:35]1)([CH3:12])([CH3:13])[CH3:14].[Cl:47][CH2:48][Cl:49].[OH:1][C:2]([C:3]([F:4])([F:5])[F:6])=[O:7]>>[NH:15]1[C:16](=[O:46])[C:17]2([c:18]3[cH:19][cH:20][c:21]([Cl:24])[cH:22][c:23]31)[CH:25]([c:39]1[c:40]([CH3:45])[cH:41][cH:42][cH:43][cH:44]1)[N:26]([CH3:38])[C:27](=[O:37])[CH2:28][CH:29]2[c:30]1[cH:31][c:32]([Cl:36])[cH:33][cH:34][cH:35]1

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 90718123racemic (2'R,3R,4'S)-6-chloro-4'-(3-chlorophenyl)-2,3-dihydro-1'-methyl-2'-(2-methylphenyl)-2,6'-dioxo spiro[indole-3,3'-piperidine]-1-carboxylic acid tert-butyl ester

Product 1

HCID 131727317racemic (2'R,3R,4'S)-6-chloro-4'-(3-chlorophenyl)-1'-methyl-2'-(2-methylphenyl)spiro[3H-indole-3,3'-piperidine]-2,6'(1H)-dione

Sources & evidence

ORD record
ord-0abf51e48f3646658bc79231ce4c7934
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (1/10)

Reaction notes

Loading…