Acetate → 1-(6-Azetidin-1-ylpyridin-3-yl)cyclopropanecarbonitrile

HRID 1559389Notes

Reaction equation

HRID 1559389 reaction equation
[C:30]([O-:31])(=[O:32])[CH3:33].[C:35]([O-:36])(=[O:37])[CH3:38].[CH2:13]1[O:14][CH2:15][CH2:16][O:17][CH2:18]1.[CH3:24][C:25]([CH3:26])([O-:27])[CH3:28].[Cl:1][c:2]1[cH:3][cH:4][c:5]([C:8]2([C:11]#[N:12])[CH2:9][CH2:10]2)[cH:6][n:7]1.[ClH:19].[NH:20]1[CH2:21][CH2:22][CH2:23]1.[Na+:29].[Pd+2:34]>>[c:2]1([N:20]2[CH2:21][CH2:22][CH2:23]2)[cH:3][cH:4][c:5]([C:8]2([C:11]#[N:12])[CH2:9][CH2:10]2)[cH:6][n:7]1

Participants

9

Reactant 8

HCID 175Acetate2×HCID 313Hydrochloric AcidHCID 923Sodium ionHCID 10422AzetidineHCID 312751,4-DioxaneHCID 105144Allyl(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)chloropalladium(II)HCID 45749132-Methylpropan-2-olateHCID 221593571-(6-Chloropyridin-3-yl)cyclopropane-1-carbonitrile

Product 1

HCID 666627061-(6-Azetidin-1-ylpyridin-3-yl)cyclopropanecarbonitrile

Sources & evidence

ORD record
ord-cc637a577cec415985b5bd6560182889
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (1/10)

Reaction notes

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