Tetrahydrofuran → (+/-)-N-[4-(3-chlorophenyl)-6-[(4-chlorophenyl)hydroxy(1-methyl-1H-imidazol-5-yl)methyl]-2-quinolinyl]-2-furancarboxamide

HRID 1559425Notes

Reaction equation

HRID 1559425 reaction equation
[CH2:42]1[O:43][CH2:44][CH2:45][CH2:46]1.[NH2:1][c:2]1[n:3][c:4]2[cH:5][cH:6][c:7]([C:19]([OH:20])([c:21]3[cH:22][n:23][cH:24][n:25]3[CH3:26])[c:27]3[cH:28][cH:29][c:30]([Cl:33])[cH:31][cH:32]3)[cH:8][c:9]2[c:10](-[c:12]2[cH:13][c:14]([Cl:18])[cH:15][cH:16][cH:17]2)[cH:11]1.[o:34]1[c:35]([C:39](=[O:40])[Cl:41])[cH:36][cH:37][cH:38]1>>[NH:1]([c:2]1[n:3][c:4]2[cH:5][cH:6][c:7]([C:19]([OH:20])([c:21]3[cH:22][n:23][cH:24][n:25]3[CH3:26])[c:27]3[cH:28][cH:29][c:30]([Cl:33])[cH:31][cH:32]3)[cH:8][c:9]2[c:10](-[c:12]2[cH:13][c:14]([Cl:18])[cH:15][cH:16][cH:17]2)[cH:11]1)[C:39]([c:35]1[o:34][cH:38][cH:37][cH:36]1)=[O:40]

Participants

4

Reactant 3

HCID 8028TetrahydrofuranHCID 682422-Furancarbonyl chlorideHCID 12083367(+/-)-2-amino-4-(3-chlorophenyl)-alpha-(4-chlorophenyl)-alpha-(1-methyl-1H-imidazol-5-yl)-6-quinolinemethanol

Product 1

HCID 22136488(+/-)-N-[4-(3-chlorophenyl)-6-[(4-chlorophenyl)hydroxy(1-methyl-1H-imidazol-5-yl)methyl]-2-quinolinyl]-2-furancarboxamide

Sources & evidence

ORD record
ord-90da7f73449143eb8bae675169f9825f
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (1/10)

Reaction notes

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