Trifluoroacetic acid → Methyl 2-(3-cyano-4-hydroxyphenyl)isonicotinate

HRID 1560536Notes

Reaction equation

HRID 1560536 reaction equation
[CH2:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[O:8][c:9]1[c:10]([C:25]#[N:26])[cH:11][c:12](-[c:15]2[cH:16][c:17]([C:18](=[O:19])[O:20][CH3:21])[cH:22][cH:23][n:24]2)[cH:13][cH:14]1.[CH3:27][c:28]1[c:29]([CH3:30])[c:31]([CH3:32])[c:33]([CH3:34])[c:35]([CH3:36])[cH:37]1.[OH:38][C:39]([C:40]([F:41])([F:42])[F:43])=[O:44]>>[OH:8][c:9]1[c:10]([C:25]#[N:26])[cH:11][c:12](-[c:15]2[cH:16][c:17]([C:18](=[O:19])[O:20][CH3:21])[cH:22][cH:23][n:24]2)[cH:13][cH:14]1

Participants

4

Reactant 3

HCID 6422Trifluoroacetic acidHCID 12784PentamethylbenzeneHCID 66995135Methyl 2-[4-(benzyloxy)-3-cyanophenyl]isonicotinate

Product 1

HCID 136368377Methyl 2-(3-cyano-4-hydroxyphenyl)isonicotinate

Sources & evidence

ORD record
ord-16668a3f4a284048a1a3a80b02276a86
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (1/10)

Reaction notes

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