反应详情

温度

50 °C

Tartaric acid (5 gm) is added to the solution of oseltamivir free base (9 gm, HPLC purity: 95.8%) in ethyl acetate (50 ml) at 25-30° C., the contents are heated to 50° C. and then slowly cooled to 30° C. in 1 hour. Filtered the solid, washed with 70 ml of ethyl acetate and dried to yield 13 gm of oseltamivir tartrate (HPLC purity: 97.2%).

1. temperatureslowly cooled to 30° C. in 1 hour
2. filtrationFiltered the solid
3. washwashed with 70 ml of ethyl acetate
4. customdried