Borane → 4-(4-Hydroxymethylphenyl)piperidine-1-carboxylic acid t-butyl ester

HRID 1561831Notes

Reaction equation

HRID 1561831 reaction equation
[BH3:1].[C:7]([CH3:8])([CH3:9])([CH3:10])[O:11][C:12](=[O:13])[N:14]1[CH2:15][CH2:16][CH:17]([c:20]2[cH:21][cH:22][c:23]([C:24](=[O:25])[OH:26])[cH:27][cH:28]2)[CH2:18][CH2:19]1.[CH2:29]1[O:30][CH2:31][CH2:32][CH2:33]1.[CH2:2]1[O:3][CH2:4][CH2:5][CH2:6]1>>[C:7]([CH3:8])([CH3:9])([CH3:10])[O:11][C:12](=[O:13])[N:14]1[CH2:15][CH2:16][CH:17]([c:20]2[cH:21][cH:22][c:23]([CH2:24][OH:25])[cH:27][cH:28]2)[CH2:18][CH2:19]1

Participants

4

Reactant 3

HCID 6331BoraneHCID 8028Tetrahydrofuran2×HCID 224928594-(4-Carboxy-phenyl)-piperidine-1-carboxylic acid tert-butyl ester

Product 1

HCID 220770564-(4-Hydroxymethylphenyl)piperidine-1-carboxylic acid t-butyl ester

Sources & evidence

ORD record
ord-3e7fd053e71c41c99f4da64bb893d017
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (1/10)

Reaction notes

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