Tetrahydrofuran → 4-(4-fluorophenyl)-N-[5-[1-(2-hydroxyethyl)-5-methylpyrazol-3-yl]-2-methylphenyl]-2-oxo-3,4-dihydro-1H-pyridine-5-carboxamide

HRID 156185Notes

Reaction equation

HRID 156185 reaction equation
[C:19]([Si:20]([CH3:21])([CH3:22])[O:24][CH2:25][CH2:26][n:27]1[n:28][c:29](-[c:33]2[cH:34][cH:35][c:36]([CH3:56])[c:37]([NH:39][C:40](=[O:41])[C:42]3=[CH:43][NH:44][C:45](=[O:55])[CH2:46][CH:47]3[c:48]3[cH:49][cH:50][c:51]([F:54])[cH:52][cH:53]3)[cH:38]2)[cH:30][c:31]1[CH3:32])([CH3:23])([CH3:57])[CH3:58].[CH2:59]1[O:60][CH2:61][CH2:62][CH2:63]1.[CH3:2][CH2:3][CH2:4][CH2:5][N+:6]([CH2:7][CH2:8][CH2:9][CH3:10])([CH2:11][CH2:12][CH2:13][CH3:14])[CH2:15][CH2:16][CH2:17][CH3:18].[F-:1]>>[OH:24][CH2:25][CH2:26][n:27]1[n:28][c:29](-[c:33]2[cH:34][cH:35][c:36]([CH3:56])[c:37]([NH:39][C:40](=[O:41])[C:42]3=[CH:43][NH:44][C:45](=[O:55])[CH2:46][CH:47]3[c:48]3[cH:49][cH:50][c:51]([F:54])[cH:52][cH:53]3)[cH:38]2)[cH:30][c:31]1[CH3:32]

Participants

5

Reactant 4

HCID 8028TetrahydrofuranHCID 16028TetrabutylammoniumHCID 28179Fluoride IonHCID 77258253HCID 77258253, compound

Product 1

HCID 759864754-(4-fluorophenyl)-N-[5-[1-(2-hydroxyethyl)-5-methylpyrazol-3-yl]-2-methylphenyl]-2-oxo-3,4-dihydro-1H-pyridine-5-carboxamide

Sources & evidence

ORD record
ord-b32d635bff0949eab967e80355b50c1c
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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