Ethanol → Ethyl 2-((cyclopentylamino)methyl)-2-fluorobutanoate

HRID 156237Notes

Reaction equation

HRID 156237 reaction equation
[CH2:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[N:8]([CH:9]1[CH2:10][CH2:11][CH2:12][CH2:13]1)[CH2:14][C:15]([C:16](=[O:17])[O:18][CH2:19][CH3:20])([CH2:21][CH3:22])[F:23].[CH3:31][CH2:32][OH:33].[F:24][C:25]([F:26])([F:27])[C:28]([OH:29])=[O:30].[OH-:34].[OH-:35].[Pd+2:36]>>[NH:8]([CH:9]1[CH2:10][CH2:11][CH2:12][CH2:13]1)[CH2:14][C:15]([C:16](=[O:17])[O:18][CH2:19][CH3:20])([CH2:21][CH3:22])[F:23]

Participants

6

Reactant 5

HCID 702EthanolHCID 961Hydroxide2×HCID 6422Trifluoroacetic acidHCID 105144Allyl(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)chloropalladium(II)HCID 57955532Ethyl 2-((benzyl(cyclopentyl)amino)methyl)-2-fluorobutanoate

Product 1

HCID 57955590Ethyl 2-((cyclopentylamino)methyl)-2-fluorobutanoate

Sources & evidence

ORD record
ord-0323f14da3064bc3a7bbf9db189c7406
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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