Acetate → Methyl 4-{3-[4-(biphenyl-2-ylcarbamoyloxy)piperidin-1-yl]propionylamino}-2,5-dimethylbenzoate

HRID 1562470Notes

Reaction equation

HRID 1562470 reaction equation
[CH3:37][N:38]([CH:39]=[O:40])[CH3:41].[CH3:71][OH:72].[I:1][c:2]1[cH:3][c:4]([CH3:36])[c:5]([NH:9][C:10](=[O:11])[CH2:12][CH2:13][N:14]2[CH2:15][CH2:16][CH:17]([O:20][C:21]([NH:22][c:23]3[c:24](-[c:29]4[cH:30][cH:31][cH:32][cH:33][cH:34]4)[cH:25][cH:26][cH:27][cH:28]3)=[O:35])[CH2:18][CH2:19]2)[cH:6][c:7]1[CH3:8].[O-:74][C:75]([CH3:76])=[O:77].[O-:78][C:79]([CH3:80])=[O:81].[Pd+2:73].[c:42]1([P:43]([c:44]2[cH:45][cH:46][cH:47][cH:48][cH:49]2)[CH2:50][CH2:51][CH2:52][P:53]([c:54]2[cH:55][cH:56][cH:57][cH:58][cH:59]2)[c:60]2[cH:61][cH:62][cH:63][cH:64][cH:65]2)[cH:66][cH:67][cH:68][cH:69][cH:70]1>>[c:2]1([C:39](=[O:40])[O:72][CH3:71])[cH:3][c:4]([CH3:36])[c:5]([NH:9][C:10](=[O:11])[CH2:12][CH2:13][N:14]2[CH2:15][CH2:16][CH:17]([O:20][C:21]([NH:22][c:23]3[c:24](-[c:29]4[cH:30][cH:31][cH:32][cH:33][cH:34]4)[cH:25][cH:26][cH:27][cH:28]3)=[O:35])[CH2:18][CH2:19]2)[cH:6][c:7]1[CH3:8]

Participants

7

Reactant 6

HCID 175Acetate2×HCID 887MethanolHCID 6228DimethylformamideHCID 812191,3-Bis(diphenylphosphino)propaneHCID 105144Allyl(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)chloropalladium(II)HCID 46239622Biphenyl-2-ylcarbamic acid 1-[2-(4-iodo-2,5-dimethylphenylcarbamoyl)ethyl]piperidin-4-yl ester

Product 1

HCID 46239621Methyl 4-{3-[4-(biphenyl-2-ylcarbamoyloxy)piperidin-1-yl]propionylamino}-2,5-dimethylbenzoate

Sources & evidence

ORD record
ord-1cddaa6724d54eb782fb61bafaf7101d
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (1/10)

Reaction notes

Loading…