Dichloromethane → 2-chloro-N'-(5-(6-(4-fluorophenyl)imidazo[2,1-b]oxazol-5-yl)pyridin-2-yl)benzohydrazide

HRID 1563532Notes

Reaction equation

HRID 1563532 reaction equation
[CH2:69]1[O:70][CH2:71][CH2:72][CH2:73]1.[Cl:59][C:60](=[O:61])[c:62]1[cH:63][cH:64][cH:65][cH:66][c:67]1[Cl:68].[Cl:74][CH2:75][Cl:76].[F:1][c:2]1[cH:3][cH:4][c:5](-[c:8]2[n:9][c:10]3[o:11][cH:12][cH:13][n:14]3[c:15]2-[c:16]2[cH:17][n:18][c:19]([NH:22][NH2:23])[cH:20][cH:21]2)[cH:6][cH:7]1.[F:24][c:25]1[cH:26][cH:27][c:28](-[c:29]2[n:30][c:31]3[n:32]([cH:33]2)[cH:34][cH:35][o:36]3)[cH:37][cH:38]1.[F:47][c:48]1[n:49][cH:50][c:51]([B:52]([OH:53])[OH:54])[cH:55][cH:56]1.[NH2:57][NH2:58].[O:39]=[C:40]1[N:41]([I:42])[C:43](=[O:44])[CH2:45][CH2:46]1>>[F:1][c:2]1[cH:3][cH:4][c:5](-[c:8]2[n:9][c:10]3[o:11][cH:12][cH:13][n:14]3[c:15]2-[c:16]2[cH:17][n:18][c:19]([NH:22][NH:23][C:60](=[O:61])[c:62]3[cH:63][cH:64][cH:65][cH:66][c:67]3[Cl:68])[cH:20][cH:21]2)[cH:6][cH:7]1

Participants

9

Reactant 8

HCID 6344DichloromethaneHCID 8028TetrahydrofuranHCID 9321HydrazineHCID 691102-Chlorobenzoyl chlorideHCID 120273N-IodosuccinimideHCID 2783397(6-Fluoropyridin-3-yl)boronic acidHCID 574336106-(4-Fluorophenyl)-imidazo[2,1-b]oxazoleHCID 594577926-(4-Fluorophenyl)-5-(6-hydrazinylpyridin-3-yl)imidazo[2,1-b]oxazole

Product 1

HCID 594578682-chloro-N'-(5-(6-(4-fluorophenyl)imidazo[2,1-b]oxazol-5-yl)pyridin-2-yl)benzohydrazide

Sources & evidence

ORD record
ord-d83f00b591b94064a9c05024e4c4dca2
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (1/10)

Reaction notes

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