Hydrochloric Acid → 5-bromo-3-(4-piperidinyl)-1H-indole-7-carboxamide

HRID 1563685Notes

Reaction equation

HRID 1563685 reaction equation
[CH3:27][OH:28].[ClH:29].[NH2:1][C:2](=[O:3])[c:4]1[cH:5][c:6]([Br:26])[cH:7][c:8]2[c:9]([CH:13]3[CH2:14][CH2:15][N:16]([C:19]([O:20][C:21]([CH3:22])([CH3:23])[CH3:24])=[O:25])[CH2:17][CH2:18]3)[cH:10][nH:11][c:12]12.[O:30]1[CH2:31][CH2:32][O:33][CH2:34][CH2:35]1>>[NH2:1][C:2](=[O:3])[c:4]1[cH:5][c:6]([Br:26])[cH:7][c:8]2[c:9]([CH:13]3[CH2:14][CH2:15][NH:16][CH2:17][CH2:18]3)[cH:10][nH:11][c:12]12

Participants

5

Reactant 4

HCID 313Hydrochloric AcidHCID 887MethanolHCID 312751,4-DioxaneHCID 59600660tert-butyl 4-(5-bromo-7-carbamoyl-1H-indol-3-yl)piperidine-1-carboxylate

Product 1

HCID 113247225-bromo-3-(4-piperidinyl)-1H-indole-7-carboxamide

Sources & evidence

ORD record
ord-f0a8921c629b455591adc4253300c638
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (1/10)

Reaction notes

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