Methanol → 4'-Chloro-3-fluoro[1,1'-biphenyl]-4-amine

HRID 1563783Notes

Reaction equation

HRID 1563783 reaction equation
[Br:18][c:19]1[cH:20][c:21]([F:26])[c:22]([NH2:23])[cH:24][cH:25]1.[CH3:27][CH2:28][O:29][C:30](=[O:31])[CH3:32].[CH3:33][OH:34].[Cl:1][c:2]1[cH:3][cH:4][c:5]([O:8][B:9]([OH:10])[OH:11])[cH:6][cH:7]1.[Na+:12].[Na+:13].[O-:14][C:15](=[O:16])[O-:17].[O:36]1[CH2:37][CH2:38][O:39][CH2:40][CH2:41]1.[OH2:35]>>[Cl:1][c:2]1[cH:3][cH:4][c:5](-[c:19]2[cH:20][c:21]([F:26])[c:22]([NH2:23])[cH:24][cH:25]2)[cH:6][cH:7]1

Participants

9

Reactant 8

HCID 887MethanolHCID 923Sodium ion2×HCID 962WaterHCID 8857Ethyl AcetateHCID 19660Carbonate IonHCID 312751,4-DioxaneHCID 1230504-Bromo-2-fluoroanilineHCID 17810664p-Chlorophenylboric acid

Product 1

HCID 200996184'-Chloro-3-fluoro[1,1'-biphenyl]-4-amine

Sources & evidence

ORD record
ord-986300d2108641fcb17bdb3dd831b281
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (1/10)

Reaction notes

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