Water → 1-(3,4,5-Trimethoxybenzyl)-3-(4-(trifluoromethyl)phenylmethyl)-3-(2-(t-butyldimethylsilyloxy)ethyl)-2-oxopyrrolidine
Reaction equation
[CH3:1][O:2][c:3]1[cH:4][c:5]([CH2:6][N:7]2[C:8](=[O:23])[CH:9]([CH2:12][c:13]3[cH:14][cH:15][c:16]([C:19]([F:20])([F:21])[F:22])[cH:17][cH:18]3)[CH2:10][CH2:11]2)[cH:24][c:25]([O:29][CH3:30])[c:26]1[O:27][CH3:28].[CH:31]([Li:32])([CH2:33][CH3:34])[CH3:35].[I:36][CH2:37][CH2:38][O:39][Si:40]([CH3:41])([CH3:42])[C:43]([CH3:44])([CH3:45])[CH3:46].[O:48]1[CH2:49][CH2:50][CH2:51][CH2:52]1.[OH2:47]>>[CH3:1][O:2][c:3]1[cH:4][c:5]([CH2:6][N:7]2[C:8](=[O:23])[C:9]([CH2:12][c:13]3[cH:14][cH:15][c:16]([C:19]([F:20])([F:21])[F:22])[cH:17][cH:18]3)([CH2:37][CH2:38][O:39][Si:40]([CH3:41])([CH3:42])[C:43]([CH3:44])([CH3:45])[CH3:46])[CH2:10][CH2:11]2)[cH:24][c:25]([O:29][CH3:30])[c:26]1[O:27][CH3:28]Participants
6
Reactant 5
Product 1
Sources & evidence
- ORD record
- ord-c2f5cc8324084646a9901bd7a87abbcf
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (1/10)
Reaction notes
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