Dichloromethane → 4-(4-Chloro-2-fluoroanilino)-7-(2-ethoxycarbonylpyrid-4-yl)methoxy-6-methoxyquinazoline
Reaction equation
[CH2:54]([P:55]([CH2:56][CH2:57][CH2:58][CH3:59])[CH2:60][CH2:61][CH2:62][CH3:63])[CH2:64][CH2:65][CH3:66].[CH2:67]([Cl:68])[Cl:69].[Cl:19][c:20]1[cH:21][c:22]([F:40])[c:23]([NH:24][c:25]2[n:26][cH:27][n:28][c:29]3[cH:30][c:31]([OH:37])[c:32]([O:35][CH3:36])[cH:33][c:34]23)[cH:38][cH:39]1.[N:1]([C:2]([N:3]1[CH2:4][CH2:5][CH2:6][CH2:7][CH2:8]1)=[O:9])=[N:10][C:11]([N:12]1[CH2:13][CH2:14][CH2:15][CH2:16][CH2:17]1)=[O:18].[OH:41][CH2:42][c:43]1[cH:44][c:45]([C:49](=[O:50])[O:51][CH2:52][CH3:53])[n:46][cH:47][cH:48]1>>[Cl:19][c:20]1[cH:21][c:22]([F:40])[c:23]([NH:24][c:25]2[n:26][cH:27][n:28][c:29]3[cH:30][c:31]([O:37][CH2:42][c:43]4[cH:44][c:45]([C:49](=[O:50])[O:51][CH2:52][CH3:53])[n:46][cH:47][cH:48]4)[c:32]([O:35][CH3:36])[cH:33][c:34]23)[cH:38][cH:39]1Participants
6
Reactant 5
Product 1
Sources & evidence
- ORD record
- ord-39456ac293b04f909e872c0b58e91b24
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (1/10)
Reaction notes
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