1-Butanol → 6-Carbamoyl-2-chloro-4-[5-(3-fluoro-5-morpholinobenzamido)-2-methylanilino]-pyrimidine
Reaction equation
[C:25]([NH2:26])(=[O:27])[c:28]1[cH:29][c:30]([Cl:35])[n:31][c:32]([Cl:34])[n:33]1.[CH2:52]([OH:53])[CH2:54][CH2:55][CH3:56].[CH3:45][CH2:46][CH2:47][CH:48]([CH3:49])[CH3:50].[CH:36]([N:37]([CH2:38][CH3:39])[CH:40]([CH3:41])[CH3:42])([CH3:43])[CH3:44].[NH2:1][c:2]1[cH:3][c:4]([NH:9][C:10]([c:11]2[cH:12][c:13]([F:23])[cH:14][c:15]([N:17]3[CH2:18][CH2:19][O:20][CH2:21][CH2:22]3)[cH:16]2)=[O:24])[cH:5][cH:6][c:7]1[CH3:8].[OH2:51]>>[NH:1]([c:2]1[cH:3][c:4]([NH:9][C:10]([c:11]2[cH:12][c:13]([F:23])[cH:14][c:15]([N:17]3[CH2:18][CH2:19][O:20][CH2:21][CH2:22]3)[cH:16]2)=[O:24])[cH:5][cH:6][c:7]1[CH3:8])[c:30]1[cH:29][c:28]([C:25]([NH2:26])=[O:27])[n:33][c:32]([Cl:34])[n:31]1Participants
7
Reactant 6
Product 1
Sources & evidence
- ORD record
- ord-07415ad10cfc4deb9159a4f0b95b657a
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (1/10)
Reaction notes
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