Dichloromethane → 3-(cyanomethyl)-3-[4-(7-[2-(trimethylsilyl)ethoxy]methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]cyclobutylmethyl methanesulfonate
Reaction equation
[CH2:32]([Cl:33])[Cl:34].[CH3:35][CH2:36][N:37]([CH2:38][CH3:39])[CH2:40][CH3:41].[CH3:42][S:43]([Cl:44])(=[O:45])=[O:46].[OH:1][CH2:2][CH:3]1[CH2:4][C:5]([n:7]2[n:8][cH:9][c:10](-[c:12]3[c:13]4[c:14]([n:15][cH:16][n:17]3)[n:18]([CH2:21][O:22][CH2:23][CH2:24][Si:25]([CH3:26])([CH3:27])[CH3:28])[cH:19][cH:20]4)[cH:11]2)([CH2:29][C:30]#[N:31])[CH2:6]1>>[O:1]([CH2:2][CH:3]1[CH2:4][C:5]([n:7]2[n:8][cH:9][c:10](-[c:12]3[c:13]4[c:14]([n:15][cH:16][n:17]3)[n:18]([CH2:21][O:22][CH2:23][CH2:24][Si:25]([CH3:26])([CH3:27])[CH3:28])[cH:19][cH:20]4)[cH:11]2)([CH2:29][C:30]#[N:31])[CH2:6]1)[S:43]([CH3:42])(=[O:45])=[O:46]Participants
5
Reactant 4
Product 1
Sources & evidence
- ORD record
- ord-4afc9c2245264b8cb2c04fe16123f773
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (1/10)
Reaction notes
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