Dichloromethane → N-(6-Chloroimidazo[1,2-b]pyridazin-8-yl)benzenesulfonamide

HRID 1565355Notes

Reaction equation

HRID 1565355 reaction equation
[Br:59][c:60]1[c:61]2[n:62]([n:63][c:64]([Cl:66])[cH:65]1)[cH:67][cH:68][n:69]2.[C:53](=[O:54])([O-:55])[O-:56].[CH2:129]1[O:130][CH2:131][CH2:132][O:133][CH2:134]1.[Cl:70][CH2:71][Cl:72].[Cs+:57].[Cs+:58].[O:111]=[C:112]([CH:113]=[CH:114][c:115]1[cH:116][cH:117][cH:118][cH:119][cH:120]1)[CH:121]=[CH:122][c:123]1[cH:124][cH:125][cH:126][cH:127][cH:128]1.[O:75]=[C:76]([CH:77]=[CH:78][c:79]1[cH:80][cH:81][cH:82][cH:83][cH:84]1)[CH:85]=[CH:86][c:87]1[cH:88][cH:89][cH:90][cH:91][cH:92]1.[O:93]=[C:94]([CH:95]=[CH:96][c:97]1[cH:98][cH:99][cH:100][cH:101][cH:102]1)[CH:103]=[CH:104][c:105]1[cH:106][cH:107][cH:108][cH:109][cH:110]1.[Pd:73].[Pd:74].[c:11]1([P:12]([c:13]2[cH:14][cH:15][cH:16][cH:17][cH:18]2)[c:19]2[c:20]3[c:44]([cH:45][cH:46][cH:47]2)[C:41]([CH3:42])([CH3:43])[c:23]2[c:22]([c:27]([P:28]([c:29]4[cH:30][cH:31][cH:32][cH:33][cH:34]4)[c:35]4[cH:36][cH:37][cH:38][cH:39][cH:40]4)[cH:26][cH:25][cH:24]2)[O:21]3)[cH:48][cH:49][cH:50][cH:51][cH:52]1.[c:1]1([S:7](=[O:8])(=[O:9])[NH2:10])[cH:2][cH:3][cH:4][cH:5][cH:6]1>>[c:1]1([S:7](=[O:8])(=[O:9])[NH:10][c:60]2[c:61]3[n:62]([n:63][c:64]([Cl:66])[cH:65]2)[cH:67][cH:68][n:69]3)[cH:2][cH:3][cH:4][cH:5][cH:6]1

Participants

10

Reactant 9

HCID 6344DichloromethaneHCID 7370BenzenesulfonamideHCID 19660Carbonate IonHCID 23938Palladium2×HCID 312751,4-DioxaneHCID 95417Dibenzylidene acetone3×HCID 104967Cesium cation2×HCID 6360441,1'-(9,9-Dimethyl-9H-xanthene-4,5-diyl)bis(1,1-diphenylphosphine)HCID 468352698-Bromo-6-chloroimidazo(1,2-b)pyridazine

Product 1

HCID 86611749N-(6-Chloroimidazo[1,2-b]pyridazin-8-yl)benzenesulfonamide

Sources & evidence

ORD record
ord-a3af785930274b65b785d1d886fb2b13
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (1/10)

Reaction notes

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