Pyridine → 1-(4-Chloro-5-(1-ethyl-7-(1-methylpiperidin-4-ylamino)-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-2-fluorophenyl)-3-phenylurea

HRID 1565667Notes

Reaction equation

HRID 1565667 reaction equation
[Cl:46][CH2:47][Cl:48].[NH2:1][c:2]1[c:3]([F:30])[cH:4][c:5]([Cl:29])[c:6](-[c:8]2[c:9](=[O:28])[n:10]([CH2:26][CH3:27])[c:11]3[cH:12][c:13]([NH:18][CH:19]4[CH2:20][CH2:21][N:22]([CH3:25])[CH2:23][CH2:24]4)[n:14][cH:15][c:16]3[cH:17]2)[cH:7]1.[O:37]=[C:38]=[N:39][c:40]1[cH:41][cH:42][cH:43][cH:44][cH:45]1.[cH:31]1[cH:32][cH:33][n:34][cH:35][cH:36]1>>[NH:1]([c:2]1[c:3]([F:30])[cH:4][c:5]([Cl:29])[c:6](-[c:8]2[c:9](=[O:28])[n:10]([CH2:26][CH3:27])[c:11]3[cH:12][c:13]([NH:18][CH:19]4[CH2:20][CH2:21][N:22]([CH3:25])[CH2:23][CH2:24]4)[n:14][cH:15][c:16]3[cH:17]2)[cH:7]1)[C:38](=[O:37])[NH:39][c:40]1[cH:41][cH:42][cH:43][cH:44][cH:45]1

Participants

5

Reactant 4

HCID 1049PyridineHCID 6344DichloromethaneHCID 7672Phenyl isocyanateHCID 867136513-(5-amino-2-chloro-4-fluorophenyl)-1-ethyl-7-(1-methylpiperidin-4-ylamino)-1,6-naphthyridin-2(1H)-one

Product 1

HCID 715850161-(4-Chloro-5-(1-ethyl-7-(1-methylpiperidin-4-ylamino)-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-2-fluorophenyl)-3-phenylurea

Sources & evidence

ORD record
ord-6e6514cdf2384b9694c97fe3dfb38f8e
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (1/10)

Reaction notes

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