Dichloromethane → Methyl 2-(4-cyclopropyl-1,4-diazepan-1-yl)pyrimidine-5-carboxylate

HRID 1565800Notes

Reaction equation

HRID 1565800 reaction equation
[CH2:22]([N:23]([CH:24]([CH3:25])[CH3:26])[CH:27]([CH3:28])[CH3:29])[CH3:30].[CH:12]1([N:15]2[CH2:16][CH2:17][NH:18][CH2:19][CH2:20][CH2:21]2)[CH2:13][CH2:14]1.[Cl:1][c:2]1[n:3][cH:4][c:5]([C:8](=[O:9])[O:10][CH3:11])[cH:6][n:7]1.[Cl:31][CH2:32][Cl:33]>>[c:2]1([N:18]2[CH2:17][CH2:16][N:15]([CH:12]3[CH2:13][CH2:14]3)[CH2:21][CH2:20][CH2:19]2)[n:3][cH:4][c:5]([C:8](=[O:9])[O:10][CH3:11])[cH:6][n:7]1

Participants

5

Reactant 4

HCID 6344DichloromethaneHCID 81531DiisopropylethylamineHCID 12627752Methyl 2-chloropyrimidine-5-carboxylateHCID 203484761-Cyclopropylhexahydro-1H-1,4-diazepine

Product 1

HCID 66589974Methyl 2-(4-cyclopropyl-1,4-diazepan-1-yl)pyrimidine-5-carboxylate

Sources & evidence

ORD record
ord-56a9e30e9afd43d1989813a51a37bfb2
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (1/10)

Reaction notes

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