N-(3-Iodo-4-methylphenyl)-4-((4methylpiperazin-1-yl) methyl)-3-(trifluoromethyl)benzamide → N-(3-[(8-aminoisoquinolin-4-yl)ethynyl]-4-methylphenyl}-4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)benzamide
Reaction equation
[C:1](#[CH:2])[c:3]1[cH:4][n:5][cH:6][c:7]2[c:8]([NH2:13])[cH:9][cH:10][cH:11][c:12]12.[I:14][c:15]1[cH:16][c:17]([NH:22][C:23]([c:24]2[cH:25][c:26]([C:38]([F:39])([F:40])[F:41])[c:27]([CH2:30][N:31]3[CH2:32][CH2:33][N:34]([CH3:37])[CH2:35][CH2:36]3)[cH:28][cH:29]2)=[O:42])[cH:18][cH:19][c:20]1[CH3:21]>>[C:1](#[C:2][c:15]1[cH:16][c:17]([NH:22][C:23]([c:24]2[cH:25][c:26]([C:38]([F:39])([F:40])[F:41])[c:27]([CH2:30][N:31]3[CH2:32][CH2:33][N:34]([CH3:37])[CH2:35][CH2:36]3)[cH:28][cH:29]2)=[O:42])[cH:18][cH:19][c:20]1[CH3:21])[c:3]1[cH:4][n:5][cH:6][c:7]2[c:8]([NH2:13])[cH:9][cH:10][cH:11][c:12]12Participants
3
Sources & evidence
- ORD record
- ord-6ffdc8afc1fc47ce8d5163e6cc4ca652
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (1/10)
Reaction notes
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