Dichloromethane → 1-(Piperidin-4-yl)azetidin-2-one

HRID 1566825Notes

Reaction equation

HRID 1566825 reaction equation
[C:1]([O:2][C:3](=[O:4])[N:8]1[CH2:9][CH2:10][CH:11]([N:14]2[C:15](=[O:18])[CH2:16][CH2:17]2)[CH2:12][CH2:13]1)([CH3:5])([CH3:6])[CH3:7].[Cl:26][CH2:27][Cl:28].[F:19][C:20]([F:21])([F:22])[C:23]([OH:24])=[O:25]>>[NH:8]1[CH2:9][CH2:10][CH:11]([N:14]2[C:15](=[O:18])[CH2:16][CH2:17]2)[CH2:12][CH2:13]1

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 581171034-(2-Oxo-azetidin-1-yl)-piperidine-1-carboxylic acid tert-butyl ester

Product 1

HCID 581170821-(Piperidin-4-yl)azetidin-2-one

Sources & evidence

ORD record
ord-875c05bbbb64433e8e5a4e2bb5ae15a8
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (1/10)

Reaction notes

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