Dichloromethane → 4-(3-Phenyl-5-isoxazolyl)piperidine

HRID 1568199Notes

Reaction equation

HRID 1568199 reaction equation
[Cl:32][CH2:33][Cl:34].[OH:25][C:26]([C:27]([F:28])([F:29])[F:30])=[O:31].[c:1]1(-[c:7]2[n:8][o:9][c:10]([CH:12]3[CH2:13][CH2:14][N:15]([C:18]([O:19][C:20]([CH3:21])([CH3:22])[CH3:23])=[O:24])[CH2:16][CH2:17]3)[cH:11]2)[cH:2][cH:3][cH:4][cH:5][cH:6]1>>[c:1]1(-[c:7]2[n:8][o:9][c:10]([CH:12]3[CH2:13][CH2:14][NH:15][CH2:16][CH2:17]3)[cH:11]2)[cH:2][cH:3][cH:4][cH:5][cH:6]1

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 59731907tert-Butyl 4-(3-phenylisoxazol-5-yl)piperidine-1-carboxylate

Product 1

HCID 597320154-(3-Phenyl-5-isoxazolyl)piperidine

Sources & evidence

ORD record
ord-89aee61682f843348d4ec2bb17f79ac2
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (1/10)

Reaction notes

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