Potassium Cation → tert-butyl 4-(6-bromo-4-(((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)carbamoyl)-1H-pyrazolo[3,4-b]pyridin-1-yl)piperidine-1-carboxylate

HRID 1568246Notes

Reaction equation

HRID 1568246 reaction equation
[Br:1][c:2]1[cH:3][c:4]([C:11](=[O:12])[NH:13][CH2:14][c:15]2[c:16](=[O:23])[nH:17][c:18]([CH3:22])[cH:19][c:20]2[CH3:21])[c:5]2[c:6]([n:7]1)[nH:8][n:9][cH:10]2.[Br:30][CH:31]1[CH2:32][CH2:33][N:34]([C:37](=[O:38])[O:39][C:40]([CH3:41])([CH3:42])[CH3:43])[CH2:35][CH2:36]1.[Cl:50][CH2:51][Cl:52].[K+:24].[K+:25].[O-:26][C:27]([O-:28])=[O:29].[O:45]=[CH:46][N:47]([CH3:48])[CH3:49].[OH2:44]>>[Br:1][c:2]1[cH:3][c:4]([C:11](=[O:12])[NH:13][CH2:14][c:15]2[c:16](=[O:23])[nH:17][c:18]([CH3:22])[cH:19][c:20]2[CH3:21])[c:5]2[c:6]([n:7]1)[n:8]([CH:31]1[CH2:32][CH2:33][N:34]([C:37](=[O:38])[O:39][C:40]([CH3:41])([CH3:42])[CH3:43])[CH2:35][CH2:36]1)[n:9][cH:10]2

Participants

8

Reactant 7

HCID 813Potassium Cation2×HCID 962WaterHCID 6228DimethylformamideHCID 6344DichloromethaneHCID 19660Carbonate IonHCID 15541517tert-Butyl 4-bromopiperidine-1-carboxylateHCID 867034116-bromo-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-1H-pyrazolo[3,4-b]pyridine-4-carboxamide

Product 1

HCID 86703412tert-butyl 4-(6-bromo-4-(((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)carbamoyl)-1H-pyrazolo[3,4-b]pyridin-1-yl)piperidine-1-carboxylate

Sources & evidence

ORD record
ord-779e53a8f619499fa04a067ba28c817e
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (1/10)

Reaction notes

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