Methanol → 4-[2-(4-Aminopiperidin-1-yl)ethyl]-6-methoxypyrido[2,3-b]pyrazin-3(4H)-one

HRID 1568733Notes

Reaction equation

HRID 1568733 reaction equation
[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]2[c:7]([n:8]([CH2:13][CH2:14][N:15]3[CH2:16][CH2:17][CH:18]([NH:21][C:22](=[O:23])[O:24][C:25]([CH3:26])([CH3:27])[CH3:28])[CH2:19][CH2:20]3)[c:9](=[O:12])[cH:10][n:11]2)[n:29]1.[CH3:34][OH:35].[Cl:36][CH2:37][Cl:38].[Cl:46][CH2:47][Cl:48].[O-:30][C:31](=[O:32])[O-:33].[OH:39][C:40]([C:41]([F:42])([F:43])[F:44])=[O:45]>>[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]2[c:7]([n:8]([CH2:13][CH2:14][N:15]3[CH2:16][CH2:17][CH:18]([NH2:21])[CH2:19][CH2:20]3)[c:9](=[O:12])[cH:10][n:11]2)[n:29]1

Participants

6

Reactant 5

HCID 887MethanolHCID 6344Dichloromethane2×HCID 6422Trifluoroacetic acidHCID 19660Carbonate IonHCID 57815384tert-Butyl {1-[2-(6-methoxy-3-oxopyrido[2,3-b]pyrazin-4(3H)-yl)ethyl]piperidin-4-yl}carbamate

Product 1

HCID 578153944-[2-(4-Aminopiperidin-1-yl)ethyl]-6-methoxypyrido[2,3-b]pyrazin-3(4H)-one

Sources & evidence

ORD record
ord-ef6111ff9fb040f39c383cd6b6a247d3
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (1/10)

Reaction notes

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