Dimethylformamide → 3-hydroxy-3-(7-methoxy-2-oxo-2H-quinolin-1-ylmethyl)-azetidine-1-carboxylic acid tert-butyl ester

HRID 1568828Notes

Reaction equation

HRID 1568828 reaction equation
[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][C:10]2([CH2:11][O:12]2)[CH2:13]1.[C:27](=[O:28])([O-:29])[O-:30].[CH3:14][O:15][c:16]1[cH:17][cH:18][c:19]2[cH:20][cH:21][c:22](=[O:26])[nH:23][c:24]2[cH:25]1.[Cs+:31].[Cs+:32].[O:33]=[CH:34][N:35]([CH3:36])[CH3:37]>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][C:10]([CH2:11][n:23]2[c:22](=[O:26])[cH:21][cH:20][c:19]3[cH:18][cH:17][c:16]([O:15][CH3:14])[cH:25][c:24]32)([OH:12])[CH2:13]1

Participants

6

Reactant 5

HCID 6228DimethylformamideHCID 19660Carbonate IonHCID 104967Cesium cation2×HCID 299427567-Methoxy-1,2-dihydroquinolin-2-oneHCID 66521770Tert-butyl 1-oxa-5-azaspiro[2.3]hexane-5-carboxylate

Product 1

HCID 671309423-hydroxy-3-(7-methoxy-2-oxo-2H-quinolin-1-ylmethyl)-azetidine-1-carboxylic acid tert-butyl ester

Sources & evidence

ORD record
ord-875898e44aea445d89a4be2cf92a9aaf
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (1/10)

Reaction notes

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