Ethanol → 4-Fluorooxane-4-carboxylic acid

HRID 1568847Notes

Reaction equation

HRID 1568847 reaction equation
[C:18]([O:19][CH2:20][CH3:21])(=[O:22])[CH3:23].[CH2:24]([OH:25])[CH3:26].[F:1][C:2]1([C:8](=[O:9])[O:10][CH2:11][c:12]2[cH:13][cH:14][cH:15][cH:16][cH:17]2)[CH2:3][CH2:4][O:5][CH2:6][CH2:7]1.[OH-:27].[OH-:29].[Pd+2:28]>>[F:1][C:2]1([C:8](=[O:9])[OH:10])[CH2:3][CH2:4][O:5][CH2:6][CH2:7]1

Participants

6

Reactant 5

HCID 702EthanolHCID 961Hydroxide2×HCID 8857Ethyl AcetateHCID 105144Allyl(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)chloropalladium(II)HCID 67232515benzyl 4-fluorotetrahydro-2H-pyran-4-carboxylate

Product 1

HCID 401522694-Fluorooxane-4-carboxylic acid

Sources & evidence

ORD record
ord-e84ae07b799545ce92f8f9e3648ef549
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (1/10)

Reaction notes

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