Tetrahydrofuran → (4-Chloro-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-(3-nitro-phenyl)-methanone

HRID 1569330Notes

Reaction equation

HRID 1569330 reaction equation
[Br:6][c:7]1[cH:8][n:9]([CH:17]2[CH2:18][CH2:19][CH2:20][CH2:21]2)[c:10]2[n:11][cH:12][n:13][c:14]([Cl:16])[c:15]12.[CH2:34]1[O:35][CH2:36][CH2:37][CH2:38]1.[CH3:1][CH2:2][CH2:3][CH2:4][Li:5].[N+:22](=[O:23])([O-:24])[c:25]1[cH:26][c:27]([C:28](=[O:29])[Cl:30])[cH:31][cH:32][cH:33]1>>[c:7]1([C:28]([c:27]2[cH:26][c:25]([N+:22](=[O:23])[O-:24])[cH:33][cH:32][cH:31]2)=[O:29])[cH:8][n:9]([CH:17]2[CH2:18][CH2:19][CH2:20][CH2:21]2)[c:10]2[n:11][cH:12][n:13][c:14]([Cl:16])[c:15]12

Participants

5

Reactant 4

HCID 8028TetrahydrofuranHCID 8495Benzoyl chloride, 3-nitro-HCID 865964995-Bromo-4-chloro-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidineHCID 178418339Butyllithium

Product 1

HCID 86760547(4-Chloro-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-(3-nitro-phenyl)-methanone

Sources & evidence

ORD record
ord-8eabc7b3973743219f561aee3ea03230
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (1/10)

Reaction notes

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