Dichloromethane → 4-(3,3-Difluoroazetidin-1-yl)piperidine

HRID 1569619Notes

Reaction equation

HRID 1569619 reaction equation
[C:1]([O:2][C:3](=[O:4])[N:8]1[CH2:9][CH2:10][CH:11]([N:14]2[CH2:15][C:16]([F:18])([F:19])[CH2:17]2)[CH2:12][CH2:13]1)([CH3:5])([CH3:6])[CH3:7].[Cl:27][CH2:28][Cl:29].[F:20][C:21]([F:22])([F:23])[C:24]([OH:25])=[O:26]>>[NH:8]1[CH2:9][CH2:10][CH:11]([N:14]2[CH2:15][C:16]([F:18])([F:19])[CH2:17]2)[CH2:12][CH2:13]1

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 59606191tert-Butyl 4-(3,3-difluoroazetidin-1-yl)piperidine-1-carboxylate

Product 1

HCID 596056804-(3,3-Difluoroazetidin-1-yl)piperidine

Sources & evidence

ORD record
ord-9ef79d79394a4e849aa377ef9a364373
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (1/10)

Reaction notes

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